SMB01324

Cyclo(His-Pro)

• Synonym(s): Cyclo(L-histidyl-L-proline), Cyclo(histidyl-proline), Cyclo(prolylhistidine), Histidylproline diketopiperazine, Histidylproline dioxopiperazine, CHP
• Empirical Formula (Hill Notation): C₁₁H₁₄N₄O₂
• CAS Number: 53109-32-3
• Molecular Weight: 234.25
• MDL number: MFCD00133207
• UNSPSC Code: 12352209
• NACRES: NA.26

Properties

• Assay: 98% (HPLC)
• Quality Level: 100
• form: solid
• color: white to off-white
• mp: 162—164 °C
• shipped in: 2-8°C
• storage temp.: −20°C
• SMILES string: O=C1N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@@H]13
• InChI: 1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1
• InChI key: NAKUGCPAQTUSBE-IUCAKERBSA-N

Description

General description

Cyclo(His-Pro) is a cyclic dipeptide consisting of the amino acids histidine (His) and proline (Pro). This small peptide forms a closed loop, with histidine and proline connected through a peptide bond. It can be found naturally in certain proteins and peptides and can also be synthesized chemically. This unique molecule is related to thyrotropin-releasing hormone and has various roles in the central nervous system. It serves as a substrate for organic cation transporters, making it essential for neuroprotection. Cyclo(His-Pro) holds promise for therapeutic applications, with the potential to counteract neuroinflammation-based degenerative conditions through both oral and parenteral administration routes. It can inhibit NF-κB nuclear accumulation and influence a range of inflammatory and stress responses, making it a valuable asset in the study of cell biology, biochemical research, and neuroprotection research.

Application

Cyclo(L-His-L-Pro) is a versatile molecule and it finds application in biochemical and metabolomics research.

Features and Benefits

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3