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27102

Sigma-Aldrich

Citric acid monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Synonym(s):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
5949-29-1
Molecular Weight:
210.14
Beilstein:
4018641
EC Number:
201-069-1
MDL number:
MFCD00149972
UNSPSC Code:
12352100
PubChem Substance ID:
57648219
NACRES:
NA.21

grade

puriss.

Assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

meets analytical specification of Ph. Eur., BP, USP, E330

impurities

residual solvents, complies
≤0.0005% heavy metals (as Pb)
7.5-8.8% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤50 mg/kg
oxalate (as oxalic acid): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg
Ca: ≤200 mg/kg
Cu: ≤10 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤10 mg/kg

suitability

complies for appearance of solution
complies for identity (IR)
complies for reaction against H2SO4

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

345.0 °F - closed cup

Flash Point(C)

173.9 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK3277
BCCH5300
BCCG2090
BCCD2310
BCBT5913

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S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
Kristine Opsvik Wikene et al.
Drug development and industrial pharmacy, 41(6), 969-977 (2014-05-21)
Bacterial resistance to antibiotics is increasing and alternative antibacterial treatments like antimicrobial photodynamic therapy (aPDT) are needed. Curcumin is under investigation as a potential photosensitizer in aPDT. The purpose of this study was to develop rapidly dissolving formulations of curcumin
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