HCYTAAB-17K

MILLIPLEX^® Human Cytokine Autoantibody Panel

• NACRES: NA.47

Properties

• species reactivity: human
• manufacturer/tradename: Milliplex^®
• technique(s): multiplexing: suitable
• detection method: fluorometric (Luminex^® xMAP^®)
• storage temp.: 2-8°C

Description

General description

Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus (SLE), multiple sclerosis (MS), Sjögren′s syndrome, rheumatoid arthritis (RA), and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.The MILLIPLEX^® MAP Human Cytokine Autoantibody Magnetic Bead Panel is a 15-plex kit to be used for the simultaneous detection and profiling of any or all of the following autoantibody analytes in serum and plasma samples: Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti-IL-8, Anti-IL-10, Anti-IL-12 (p40), Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, and Anti-TNFα. For this particular panel, 4 assay control beads are also included as part of the base kit format.

Application

The Human Cytokine Autoantibody panel is a bead-based multiplex assay based on the Luminex^® xMAP technology which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.This is assay yields results in Median Fluorescence Intensity (MFI).Four assay control beads are included in the base kit.This is an overnight or 2 hour incubation assay.This assay requires 25 μL of 1:100 diluted plasma or serum.Analytes available:BAFF/Blys;G-CSF;IFNβ;IFNγ;IL-1α;IL-6;IL-8;IL-10;IL-12 (p40);IL-15;IL-17A;IL-17F;IL-18;IL-22;TNFα

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

96-well plate

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H317,H319,H411
• Precautionary Statements: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable