654257

TNF-α Antagonist III, R-7050

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

• Synonym(s): TNF-α Antagonist III, R-7050, 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
• Empirical Formula (Hill Notation): C₁₆H₈ClF₃N₄S
• CAS Number: 303997-35-5
• Molecular Weight: 380.77
• MDL number: MFCD00140737
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: light yellow
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
• InChI key: SUUMKHOVGVYGOP-UHFFFAOYSA-N

Description

General description

A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC₅₀ = 0.631 and 1.45 µM, respectively) in A549 cells.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable