329600

Erastin

≥98% (HPLC), solid, antitumor agent, Calbiochem^®

• Synonym(s): Erastin, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
• Empirical Formula (Hill Notation): C₃₀H₃₁ClN₄O₄
• CAS Number: 571203-78-6
• Molecular Weight: 547.04
• MDL number: MFCD09837984
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
• InChI key: BKQFRNYHFIQEKN-UHFFFAOYSA-N

Description

General description

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC₅₀ = 6.0 µM in BJ-TERT/LT/ST/RAS^V12 cells).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yagoda, N., et al. 2007. Nature447, 864.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable