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Sigma-Aldrich

Caspase-8 Inhibitor II

≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem®

Synonym(s):

Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C30H43FN4O11
Molecular Weight:
654.68
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to yellow

solubility

DMSO: 10 mM

shipped in

ambient

storage temp.

−20°C

General description

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-8
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

Analysis Note

≥98% (HPLC)

Other Notes

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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