R-011
Ritalinic acid hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C13H17NO2 · HCl
CAS Number:
Molecular Weight:
255.74
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol (as free base)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
SMILES string
Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI
1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI key
SCUMDQFFZZGUQY-UHFFFAOYSA-N
General description
Ritalin®ic acid is a primary blood metabolite of methylphenidate, a psychostimulant sold under trade names Concerta® and Ritalin®. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Methylphenidate is prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia, and narcolepsy.
Application
- Genotoxicity research in non-human primates: Ritalinic acid hydrochloride, a primary metabolite of methylphenidate, is used in genetic toxicology studies to evaluate potential genotoxic effects, aiding in the assessment of safety profiles for neuropharmacological treatments (Morris et al., 2009).
- Pharmacokinetics and mutagenicity studies: Ritalinic acid hydrochloride is used in dose-range and mutagenicity research. It helps in studying the pharmacokinetics and toxicological impact of methylphenidate, offering important insights into its safety and effectiveness in therapeutic applications (Manjanatha et al., 2008).
- Bioequivalence and food effect studies: In clinical pharmacology, ritalinic acid hydrochloride is instrumental in conducting bioequivalence studies of dexmethylphenidate, examining the influence of food on drug absorption and metabolism, crucial for optimizing drug administration protocols (Teo et al., 2004).
- Childhood pharmacotherapy: Research using ritalinic acid hydrochloride explores the effects of methylphenidate when administered with or without food, highlighting its impact on the plasma concentration of the drug and its acid metabolite, informing pediatric dosing guidelines (Chan et al., 1983).
- Hyperkinetic disorders treatment studies: Ritalinic acid hydrochloride supports pharmacokinetic studies in children with hyperkinetic disorders, aiding in understanding how methylphenidate behaves within the body to improve therapeutic strategies (Hungund et al., 1979).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
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Mugimane G Manjanatha et al.
Environmental and molecular mutagenesis, 49(8), 585-593 (2008-07-12)
Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate
Maria del Mar Ramirez Fernandez et al.
Journal of analytical toxicology, 31(8), 497-504 (2007-11-09)
A validated method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and several metabolites is presented. The procedure comprises a sample clean-up step, using mixed-mode solid-phase extraction followed by liquid chromatography (LC)-tandem mass spectrometry analysis. Chromatographic separation
Emilia Marchei et al.
Clinical chemistry, 56(4), 585-592 (2010-02-20)
We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration. We analyzed oral fluid and
Nicolas Barbarin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 783(1), 73-83 (2002-11-27)
This work presents a high-throughput selected reaction monitoring (SRM) LC-MS method for the determination of methylphenidate (MPH), a central nervous stimulant, and its de-esterified metabolite, ritalinic acid (RA) in rat plasma samples. A separation of these two compounds was achieved
Aygul Balcioglu et al.
Neuropharmacology, 57(7-8), 687-693 (2009-07-28)
Methylphenidate is a frequently prescribed stimulant for the treatment of attention deficit hyperactivity disorder (ADHD). An important assumption in the animal models that have been employed to study methylphenidate's effects on the brain and behavior is that bioavailability of methylphenidate
Articles
As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance.
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