E-081
Etizolam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C17H15ClN4S
CAS Number:
Molecular Weight:
342.85
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland)
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
CCC1=CC2=C(S1)N3C(CN=C2C4=CC=CC=C4Cl)=NN=C3C
InChI
1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3
InChI key
VMZUTJCNQWMAGF-UHFFFAOYSA-N
General description
A certified solution standard for use in LC/MS or GC/MS benzodiazepine testing methods in clinical toxicology, urine drug testing, or forensic analysis. Etizolam, sold under brand names such as Etilaam, Etizola, or Depas, is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety, or panic attacks. Etizolam is also sold on the designer drug market with cases of abuse noted in Europe and the US.
Application
- A strategy for the detection of benzodiazepine drugs using low-resolution paper-spray mass spectrometry for harm reduction drug checking: This study explores the application of Etizolam in the development of low-cost, rapid mass spectrometric techniques for detecting benzodiazepines at harm reduction sites, emphasizing its utility in public health interventions (Miskulin et al., 2023).
- Unexpected results found in larvae samples from two postmortem forensic cases: Incorporates Etizolam to elucidate drug metabolism in forensic toxicology, highlighting its relevance in the postmortem analysis and its impact on forensic investigations (Groth et al., 2022).
- Rapid and accurate etizolam detection using surface-enhanced Raman spectroscopy for community drug checking: Demonstrates the use of Etizolam as a standard in developing cutting-edge, reliable spectroscopic methods for quick drug testing in community settings, thus advancing forensic and clinical toxicology (Gozdzialski et al., 2022).
- Incorporation of five common hypnotics into hair after a single dose and application to a forensic case of drug facilitated crimes: This research utilizes Etizolam in studies focused on drug deposition in hair, providing crucial insights for the forensic analysis of drug-facilitated crimes (Sasaki et al., 2021).
Biochem/physiol Actions
Etizolam is a thienodiazepine anxiolytic and as compared to other benzodiazepines has lower dependence potential. It differs from other benzodiazepines in that its molecules possess a thiophene ring instead of benzene. It has anticonvulsant, sedative, anxiolytic, amnesic, hypnotic and muscle relaxant properties. It′s mode of action is through benzodiazepine receptor. It is used to treat insomnia, moderate depression and social anxiety disorder, and has occasionally been associated with blepharospasm and skin lesions.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F
Flash Point(C)
9.7 °C
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Encyclopedia of Psychopharmacology
Ian Stolerman
Springer Science & Business Media, 502-502 (2010)
Sumit Gupta et al.
Indian journal of pharmacology, 46(6), 655-656 (2014-12-30)
Etizolam is a thienodiazepine anxiolytic which is said to have lower dependence potential than other benzodiazepines. We report a case of etizolam dependence in a young male with social anxiety disorder and moderate depression. This case report highlights the fact
Toshiaki Makino et al.
Biological & pharmaceutical bulletin, 28(2), 280-284 (2005-02-03)
Kamisyoyosan (KSS) and Tokisyakuyakusan (TSS) are widely used herbal formulas in Japanese traditional kampo medicine to relieve the symptoms occurred in climacteric disturbance. Since Japanese physicians frequently prescribe these formulas combined with etizolam, one of benzodiazepine anxiolytics, we evaluated the
[Practical analysis of toxic substances useful for clinical toxicology--10--benzodiazepine].
Yasushi Hori et al.
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 17(2), 163-168 (2004-07-23)
Yutaka Hirashima et al.
Neurologia medico-chirurgica, 45(12), 621-626 (2005-12-27)
Inflammatory reaction is very important for formation of the neomembrane of chronic subdural hematoma (CSDH). The present study evaluated medical treatment with the platelet-activating factor receptor antagonist, etizolam, for the resolution of CSDH, and the factors indicating surgery or conservative
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