999998P

06:0 Diether PC

Avanti Research^™ - A Croda Brand 999998P, powder

• Synonym(s): 1,2-di-O-hexyl-sn-glycero-3-phosphocholine
• Empirical Formula (Hill Notation): C₂₀H₄₄NO₆P
• CAS Number: 79645-39-9
• Molecular Weight: 425.54
• MDL number: MFCD02259319
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 10 mg (999998P-10mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 999998P
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCC)COCCCCCC)=O
• InChI: 1S/C20H44NO6P/c1-6-8-10-12-15-24-18-20(25-16-13-11-9-7-2)19-27-28(22,23)26-17-14-21(3,4)5/h20H,6-19H2,1-5H3/t20-/m1/s1

Description

General description

06:0 Diether PC (phosphocholine) is a glycerophospholipid having two hexane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It has choline as the alcohol moiety, attached to the phosphate group.

Application

06:0 Diether PC or 1,2-di-O-hexyl-sn-glycero-3-phosphocholine might be used:

• in bicelle media to measure the H—C one-bond residual dipolar couplings for trisaccharides, Lewis X (Lex) and Lewis A (Lea) methyl glycosides using nuclear magnetic resonance (NMR) residual dipolar couplings
• to compose isotropically tumbling small bicelles, to study its size and morphology by 31P NMR and atomic force microscopy (AFM)
• in bicelle preparation for NMR studies

Biochem/physiol Actions

06:0 Diether PC (phosphocholine) is useful for bicelles preparation. Bicelles can be integrated into standard crystallization protocols and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Incorporating 06:0 Diether PC in bicelles results in bicelles similar to conventional phospholipid bicelles but with improved chemical stability.

Packaging

5 mL Clear Glass Sealed Ampule (999998P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3