810120P
Avanti
18:0 PEG2000 PE CF
Avanti Research™ - A Croda Brand 810120P, powder
Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (ammonium salt)
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About This Item
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810120P-1mg)
pkg of 1 × 500 μg (810120P-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810120P
shipped in
dry ice
storage temp.
−20°C
General description
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) lipid comprises hydrophilic polyethylene glycol (PEG) polymer in its head groups. DSPE-PEG(2000) micelles exist as spheroid in aqueous solution.
Application
18:0 PEG2000 PE CF may be used:
- in in vitro release assays from nanoemulsion (NE)
- for the labeling PEGylated LPD (liposome-polycation-DNA) for size exclusion chromatography studies
- as a fluorescent probe to monitor shape transformation in giant vesicles
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) micelles aid in nanoparticles based drug delivery. It has potential to solubilize hydrophobic drugs and aid in the controlled release of drugs. 18:0 PEG2000 PE CF also called the DSPE−PEG2000, prevents the uptake of drugs by mononuclear phagocyte system and is a potential drug carrier for cancer therapy.
Packaging
5 mL Clear Glass Sealed Ampule (810120P-1mg)
5 mL Clear Glass Sealed Ampule (810120P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Repeated injections of PEG-PE liposomes generate anti-PEG antibodies
Sroda K, et al.
Cellular & Molecular Biology Letters, 10, 37-47 (2005)
Shape Transformations of Lipid Vesicles by Insertion of Bulky-Head Lipids
Tsuda S, et al.
PLoS ONE, 10(7), e0132963-e0132963 (2015)
Nanoparticles evading the reticuloendothelial system: role of the supported bilayer
Li SD and Huang L
Biochimica et Biophysica Acta - Biomembranes, 1788(10), 2259-2266 (2009)
Yasuhiro Kakimoto et al.
Langmuir : the ACS journal of surfaces and colloids, 34(24), 7201-7209 (2018-05-24)
Lipid molecules such as glycolipids that are modified with hydrophilic biopolymers participate in the biochemical reactions occurring on cell membranes. Their functions and efficiency are determined by the formation of microdomains and their physical properties. We investigated the morphology and
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