P2139

Poly(ethylene glycol)

average mol wt 8,000, powder

• Synonym(s): Polyethylene glycol, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 12352104
• PubChem Substance ID: 24898275
• NACRES: NA.23

Properties

• form: powder
• Quality Level: 200
• mol wt: average mol wt 8,000
• solubility: water: soluble (PEG is soluble in water approximately 630 mg/ml, 20 °C)
• density: 1.0845 g/mL at 70 °C; 1.0689 g/mL at 90 °C
• Ω-end: hydroxyl
• α-end: hydroxyl
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response

Application

Poly (ethylene glycol) can be used in the formulation of the drug to improve its dissolution rate and oral bioavailability.

PEG can be used for the effective isolation of edible nanoparticles (ENPs) which have excellent anti-cancer and anti-inflammatory activities. PEG is a crowding agent and forms a net-like mesh in which nanovesicles are trapped and precipitated. For example, ginger-derived ENPs are isolated using a PEG-based method which is cost-effective compared to ultracentrifugation.

PEG can be used as a precursor to synthesize degradable hydrogels for the controlled release of hydrophilic and high molecular weight pharmaceuticals.

Features and Benefits

• Highstructural flexibility
• Biocompatibility
• Amphiphilicity
• Highhydration capacity
• Devoidof any steric hindrance

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves