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Key Documents

L070000

Sigma-Aldrich

Fast Deprotection Cap A

45-55 g/L (TAC2O content, gravimetric)

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About This Item

UNSPSC Code:
41116105
NACRES:
NA.21

type

for DNA synthesis
for DNA synthesis

product line

Proligo Reagents

form

liquid

storage condition

dry at room temperature

concentration

45-55 g/L (TAC2O content, gravimetric)

color

clear

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General description

Fast Deprotection Cap A contains tert-butylphenoxyacetyl aceticanhydride (TAC2O) in tetrahydrofuran, which ensures thedisplacement of tert-butylphenoxyacetyl (TAC) on guanine bases doesnot occur.

Preparation Note

Tetrahydrofurane / TAC2O 100/5 (v/w)

Other Notes

Fast Deprotection Cap A solution must be used for synthesis with Sigma-Aldrich′s TAC-protected phosphoramidites. Fast Deprotection Cap A solution, containing tert-butylphenoxyacetyl acetic anhydride (TAC2O) in tetrahydrofuran, is used in place of Cap A solution to ensure that the displacement of tert-butylphenoxyacetyl (TAC) on guanine bases of the TAC-protected DNA and RNA phosphoramidites does not occur.

Signal Word

Danger

Hazard Statements

H225,H319,H335,H336,H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

6.1 °F

Flash Point(C)

-14.4 °C

Certificates of Analysis (COA)

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