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E14403

Sigma-Aldrich

Ethyl α-bromoisobutyrate

98%

Synonym(s):

Ethyl 2-bromo-2-methylpropionate

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About This Item

Linear Formula:
(CH3)2CBrCOOC2H5
CAS Number:
Molecular Weight:
195.05
Beilstein:
1098947
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

liquid

refractive index

n20/D 1.444 (lit.)

bp

65-67 °C/11 mmHg (lit.)

density

1.329 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C(C)(C)Br

InChI

1S/C6H11BrO2/c1-4-9-5(8)6(2,3)7/h4H2,1-3H3

InChI key

IOLQWGVDEFWYNP-UHFFFAOYSA-N

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General description

Ethyl α-bromoisobutyrate is an organic bromoester used as an initiator in controlled radical polymerization reactions.

Application

Atom Transfer Radical Polymerization (ATRP) initiator that will generate a polymer with an ethyl end group.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

140.0 °F - closed cup

Flash Point(C)

60 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Na Wang et al.
Analytical methods : advancing methods and applications, 12(36), 4438-4446 (2020-08-29)
As robust functional polymers, polymer brush-based hybrid nanomaterials have potential application in the highly sensitive determination of tumor markers (TMs). Currently, there are plentiful reports on the polymerization methods of functional polymer brushes. Low ppm ATRP (activators (re)generated by electron
Hailing He et al.
Materials (Basel, Switzerland), 12(16) (2019-08-10)
The balance of strengthening and toughening of poly (lactic acid) (PLA) has been an intractable challenge of PLA nanocomposite development for many years. In this paper, core-shell nanoparticles consisting of a silica rigid core and poly (butyl acrylate) (PBA) flexible
Renata Studzińska et al.
Chemistry & biodiversity, 16(6), e1900065-e1900065 (2019-04-24)
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an enzyme that affects the body's cortisol levels. The inhibition of its activity can be used in the treatment of Cushing's syndrome, metabolic syndrome and type 2 diabetes. In this study, we synthesized new
Jing Wang et al.
ACS applied materials & interfaces, 7(9), 5454-5461 (2015-02-19)
Nonspherical spindle-shaped hematite/polymer hybrid nanoparticles (SPNPs) were synthesized via surface-initiated atom transfer radical polymerization (SI-ATRP). The long axis of the SPNPs was 370 ± 65 nm, and the short axis was 80 ± 15 nm with an aspect ratio of
Paulina Maksym-Bębenek et al.
Macromolecular bioscience, 15(11), 1616-1624 (2015-07-23)
The core-shell micelles in aqueous solutions were prepared at low CAC values (<0.1 mg · mL(-1) ) from amphiphilic graft copolymers consisting of poly(methyl methacrylate) backbone (120-165 units) with loosely grafted (17-40%) hydroxyl-capped PEG (9 vs 6 units in side chain) for drug

Articles

Find how atom transfer radical polymerization (ATRP) tools can be used for the synthesis of well-defined functionalized polymers.

Atom transfer radical polymerization (ATRP) has emerged as one of the most successful synthetic techniques for the preparation of polymers with predetermined molecular weights, narrow molecular weight distributions, and high degrees of chain end functionalities.

ATRP polymerization, chain transfer agent, living polymerization, functional telechelic polymers

Applying ARGET ATRP to the Growth of Polymer Brush Thin Films by Surface-initiated Polymerization

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Protocols

An article about the typical procedures for polymerizing via ATRP, which demonstrates that in the following two procedures describe two ATRP polymerization reactions as performed by Prof. Dave Hadddleton′s research group at the University of Warwick.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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