929484

FBnG-C3-PEG₁-C3-NH₂ hydrochloride

≥95%

• Synonym(s): (R)-2-acetamido-3-((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)-N-(3-(3-aminopropoxy)propyl)propanamide hydrochloride
• Empirical Formula (Hill Notation): C₂₃H₃₁FN₈O₄S · xHCl
• Molecular Weight: 534.61 (free base basis)

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(NCCCOCCCN)=O)NC(C)=O)N2CC3=CC=C(C=C3)F.Cl

Description

Application

Protein degrader building block FBnG-C₃-PEG₁-C₃-NH₂ hydrochloride enables the synthesis of molecules for degradation of proteins and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a p-fluorobenzylguanine (FBnG) ligand, a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation



Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable