900618

3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine

95%

• Synonym(s): Bromo diazirine alkyne, Probe building block
• Empirical Formula (Hill Notation): C₁₁H₆BrF₃N₂
• CAS Number: 849607-28-9
• Molecular Weight: 303.08
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Assay: 95%
• form: solid
• availability: available only in USA
• storage temp.: −20°C

Description

Application

3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca²⁺ release from sarcoplasmic reticulum of skeletal muscle

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H242
• Precautionary Statements: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable