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363502

Sigma-Aldrich

Poly[(R)-3-hydroxybutyric acid]

natural origin

Synonym(s):

(R)-3-Hydroxybutyric acid polymerized, PHB

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About This Item

Linear Formula:
[COCH2CH(CH3)O]n
CAS Number:
29435-48-1
MDL number:
MFCD00134263
UNSPSC Code:
12162002
PubChem Substance ID:
24862200
NACRES:
NA.23

transition temp

Tm 172 °C (DSC)

SMILES string

CC(O)CC(O)=O

InChI

1S/C12H20O6/c1-8(14)6-11(15)18-10(3)7-12(16)17-9(2)4-5-13/h5,8-10,14H,4,6-7H2,1-3H3

InChI key

QLACRIKFZRFWRU-UHFFFAOYSA-N

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General description

Biocompatible, biodegradable polymer.

Application

Poly[(R)-3-hydroxybutyric acid (PHB) is a biodegradable and biocompatible polymer produced by several bacterial species, owing to its low resorbability and tunable properties, it may find uses in a variety of applications such as tissue engineering, controlled release systems etc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds.
Ricotti L, et al.
Biomedical Materials (Bristol, England), 7(3), 035010-035010 (2012)
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.
Sandstrom A G, et al.
AMB Express, 5(1), 14-14 (2015)
Molecular mass of poly [(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.
Kusaka S, et al.
Applied Microbiology and Biotechnology, 47(2), 140-143 (1997)
Rosetta N Reusch
Chemistry & biodiversity, 9(11), 2343-2366 (2012-11-20)
Poly-(R)-3-hydroxybutyrates (PHB), linear polymers of (R)-3-hydroxybutyrate, are components of all biological cells in which short polymers (<200 monomer residues) are covalently attached to certain proteins and/or noncovalently associated with polyphosphates - inorganic polyphosphate (polyP), RNA, and DNA. The low concentrations
Asli S Ciggin et al.
Bioresource technology, 129, 118-126 (2012-12-13)
The aerobic metabolism of a mixture of acetate and starch was studied with main emphasis on their interaction and the effect on their storage as PHB and glycogen, respectively. Pulse feeding strongly increased the storage of both substrates; however, the
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