130001
1-Methylpiperazine
99%
Synonym(s):
N-Methylpiperazine
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vapor density
3.5 (vs air)
Quality Level
Assay
99%
form
liquid
refractive index
n20/D 1.466 (lit.)
bp
138 °C (lit.)
density
0.903 g/mL at 25 °C (lit.)
SMILES string
CN1CCNCC1
InChI
1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
InChI key
PVOAHINGSUIXLS-UHFFFAOYSA-N
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General description
1-Methylpiperazine is a heterocyclic diamine used as a versatile building block and intermediate in organic synthesis.
Application
1-Methylpiperazine was used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
88.7 °F - closed cup
Flash Point(C)
31.5 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Journal of chromatography. A, 1297, 77-84 (2013-06-01)
This paper reports the preparation of a novel, silica-based, strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative. To prepare the difunctional strong anion-exchange stationary phase, activated silica beads were first bonded with 3-chloropropyltriethoxysilane and then reacted with 1-methylpiperazine followed by
The Analyst, 137(12), 2884-2890 (2012-05-04)
A highly selective molecularly imprinted solid-phase extraction (MISPE) combined with liquid chromatography-ultraviolet detection was developed for the simultaneous isolation and determination of four plant hormones including indole-3-acetic acid (IAA), indole-3-propionic acid (IPA), indole-3-butyric acid (IBA) and 1-naphthaleneacetic acid (NAA) in
International archives of allergy and applied immunology, 79(3), 259-262 (1986-01-01)
The presence of specific IgE antibodies against conjugates between human serum albumin and piperazine, a compound previously known to cause occupational asthma, and N-methyl-piperazine, respectively, was demonstrated by RAST, RAST inhibition and skin prick tests in 2 asthmatic subjects occupationally
Journal of biomedical materials research, 39(4), 667-672 (1998-03-10)
Aminated poly(vinyl chloride) (PVC) membranes were prepared that had a Nernstian response over a wide range of pH. The reaction between PVC and methyl-piperazine (MePIP) in dimethylformamide (DMF) was studied over a wide range of time and temperature, and in
Carcinogenesis, 8(12), 1907-1912 (1987-12-01)
Human exposure to endogenously formed N-nitroso compounds has frequently been suggested as a causative factor in carcinogenesis where this is related to chronic bacterial infection such as is seen in gastric achlorhydria. At least two distinct mechanisms of endogenous formation
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