Z4250
Zymosan A from Saccharomyces cerevisiae
for inducing inflamatory response
Synonym(s):
Yeast Cell Wall
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About This Item
Recommended Products
biological source
Saccharomyces cerevisiae
Quality Level
form
powder with small lumps
technique(s)
flow cytometry: suitable
tissue culture: suitable
color
off-white to light brown
storage temp.
2-8°C
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Application
- in flow cytometry
- to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)
Zymosan A from Saccharomyces cerevisiae has been used:
- as a positive control to determine the activation of complement cascade
- for respiratory burst (RB) assay
- to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
- a stimulating agent in Krebs-Ringer phosphate (KRP) medium
- to induce thermal hyperalgesia in mice
Biochem/physiol Actions
Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells
Sun Y, et al.
Cell Stress & Chaperones, 23(5), 1069-1078 (2018)
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue
Kern K, et al.
Frontiers in Immunology, 9, 2261-2261 (2018)
Impact of copper nanoparticles on porcine neutrophils: ultrasensitive characterization factor combining chemiluminescence information and USEtox assessment model
Pu Y, et al.
Materials Today Communications, 11, 68-75 (2017)
Self-mineralizing Ca-enriched Methacrylated Gellan Gum Beads for Bone Tissue Engineering
VieiraS, et al.
Acta Biomaterialia (2019)
Maria M M Kaisar et al.
PLoS biology, 16(4), e2005504-e2005504 (2018-04-19)
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive
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