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T133

Sigma-Aldrich

Inactin® hydrate

≥98% (HPLC)

Synonym(s):

Thiobutabarbital sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C10H15N2NaO2S · xH2O
CAS Number:
947-08-0
Molecular Weight:
250.29 (anhydrous basis)
EC Number:
213-425-3
MDL number:
MFCD00214068
UNSPSC Code:
12352200
PubChem Substance ID:
24899957
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

color

light yellow

solubility

H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)

SMILES string

[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O

InChI

1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

InChI key

SLZHLQUFNFXTHB-UHFFFAOYSA-M

Application

Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).

Biochem/physiol Actions

Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.

Legal Information

Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A C Ailiani et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(10), 1477-1486 (2014-09-27)
Anesthetics are commonly applied in animal studies of gastrointestinal (GI) function. Different anesthetics alter smooth-muscle motility in different ways. The aim of this study is to quantify and compare non-invasively with magnetic resonance imaging (MRI) the motility patterns of the
Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
Flecknell
Laboratory Animal Anesthesia. An introduction for Research Workers and Technicians, 36-36 (1987)
Jing Li et al.
American journal of physiology. Renal physiology, 313(2), F505-F513 (2017-06-02)
We studied gender differences in Na
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