SRP8036

IL-36β mouse

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized

• Synonym(s): Interleukin-1 family member 8, Interleukin-36β, Sentrin-specific protease 2
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• product name: IL-36β mouse, recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
• biological source: mouse
• recombinant: expressed in E. coli
• conjugate: untagged
• Assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~17 kDa
• packaging: pkg of 10 μg
• impurities: <0.01 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: Q9D6Z6
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Il36b(69677)

Description

General description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Physical form

Lyophilized from PBS and 0.5% trehalose.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-36beta (mouse) (aa 31-183) is untagged.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable