SML3074

Gap26 trifluoroacetate

≥95% (HPLC)

• Synonym(s): Gap 26 trifluoroacetate, Gap-26 trifluoroacetate, L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-?-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-, trifluoroacetate, VCYDKSFPISHVR trifluoroacetate, Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg trifluoroacetate
• Empirical Formula (Hill Notation): C₇₀H₁₀₇N₁₉O₁₉S · xC₂HF₃O₂
• CAS Number: 197250-15-0
• Molecular Weight: 1550.78 (free base basis)
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: film or powder
• color: white to off-white
• storage temp.: −20°C
• InChI: 1S/C70H107N19O19S/c1-7-38(6)56(67(105)85-50(33-91)61(99)81-46(29-41-31-75-35-77-41)60(98)87-55(37(4)5)66(104)79-44(69(107)108)18-13-25-76-70(73)74)88-64(102)52-19-14-26-89(52)68(106)48(28-39-15-9-8-10-16-39)83-62(100)49(32-90)84-57(95)43(17-11-12-24-71)78-59(97)47(30-53(93)94)82-58(96)45(27-40-20-22-42(92)23-21-40)80-63(101)51(34-109)86-65(103)54(72)36(2)3/h8-10,15-16,20-23,31,35-38,43-52,54-56,90-92,109H,7,11-14,17-19,24-30,32-34,71-72H2,1-6H3,(H,75,77)(H,78,97)(H,79,104)(H,80,101)(H,81,99)(H,82,96)(H,83,100)(H,84,95)(H,85,105)(H,86,103)(H,87,98)(H,88,102)(H,93,94)(H,107,108)(H4,73,74,76)/t38-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,54-,55-,56-/m0/s1
• InChI key: FDPIMWZHGJNESB-VCSXYVMHSA-N

Description

Biochem/physiol Actions

Gap 26 is a 13-mer peptide derived from the first extracellular loop I sequence of connexin-43 (h/m/r Cx43 aa64-76 or aa63-75 after Met1 removal). Gap 26 is widely employed to block and probe Cx43-mediated gap junctional signaling in cultures (20-160 μM) and in animals in vivo.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable