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Key Documents

SML0668

Sigma-Aldrich

Calhex 231 hydrochloride

≥98% (HPLC)

Synonym(s):

4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C25H27ClN2O · HCl
CAS Number:
652973-93-8
Molecular Weight:
443.41
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

Application

Calhex 231 hydrochloride has been used:
  • as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
  • to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
  • to test its effect on acoustic response bias in zebrafish
  • in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

Biochem/physiol Actions

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Toshiya Minakata et al.
Frontiers in molecular neuroscience, 12, 175-175 (2019-08-06)
Maintaining Ca2+ homeostasis in lymphatic fluids is necessary for proper hearing. Despite its significance, the mechanisms that maintain the cochlear lymphatic Ca2+ concentrations within a certain range are not fully clarified. We investigated the functional expression of calcium-sensing receptor (CaSR)
Roshan A Jain et al.
Current biology : CB, 28(9), 1357-1369 (2018-04-24)
Animals continuously integrate sensory information and select contextually appropriate responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli from a pre-existing choice repertoire in a context-dependent manner. We demonstrate that this sensorimotor choice is modulated
Pamela Mattar et al.
International journal of molecular sciences, 21(20) (2020-10-21)
Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is to understand the role of CaSR on autophagy in AT

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