SAB5700277

Anti-Phospho-APP-T668 antibody produced in rabbit

• Synonym(s): Aβ42, AAA, ABETA, ABPP, AD1, APP, APPI, Amyloid beta A4, CTFgamma, CVAP, PN-II, PN2, preA4
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 34; 72-86
• species reactivity: rat, mouse
• concentration: 0.81 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P05067
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr668)
• Gene Information: human ... APP(351)

Description

General description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Immunogen

A phospho specific peptide corresponding to residues surrounding T668 of human APP

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable