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Key Documents

P2870

Sigma-Aldrich

Pristane

synthetic, ≥98% (GC)

Synonym(s):

Norphytane, 2,6,10,14-Tetramethylpentadecane

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About This Item

Linear Formula:
(CH3)2CH(CH2)3CH(CH3)(CH2)3CH(CH3)(CH2)3CH(CH3)2
CAS Number:
Molecular Weight:
268.52
Beilstein:
1720538
EC Number:
MDL number:
UNSPSC Code:
12352001
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic

Quality Level

Assay

≥98% (GC)

form

liquid

mol wt

268.5

storage condition

(tightly closed)

color

colorless

refractive index

n20/D 1.438 (lit.)

bp

68 °C/0.001 mmHg (lit.)

solubility

hexane: miscible 10 % (v/v)

density

0.783 g/mL at 20 °C (lit.)

storage temp.

room temp

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC(C)C

InChI

1S/C19H40/c1-16(2)10-7-12-18(5)14-9-15-19(6)13-8-11-17(3)4/h16-19H,7-15H2,1-6H3

InChI key

XOJVVFBFDXDTEG-UHFFFAOYSA-N

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General description

Pristane, also known as norphytane, is a saturated norterpenoid alkane derived from phytane. Its immunological properties are valuable for various applications, serving as an inflammation-inducing agent in tumorigenesis and autoimmune disease induction, facilitating research on conditions like rheumatoid arthritis and lupus. Pristane′s diverse applications span acting as an immunological adjuvant, inducing autoimmune diseases, facilitating monoclonal antibody production, and serving as an energy source, making it a valuable asset in biochemical research, cell culture, and molecular biology.

Application

Pristane also acts as an immunological adjuvant for generating monoclonal antibodies in mouse ascites and finds use as a biological marker. Additionally, pristane can also be used as the primary carbon and energy source for the growth of a bacterial strain, coryneform soil isolate. Its distinctive ability to induce plasmacytomas is particularly valuable for studying B-cell tumors like Burkitt′s lymphoma.
It is commonly used for priming animals, leading to granulomatous inflammation and disruption of local lymphatic drainage, resulting in increased ascitic yields. It has been used to induce systemic lupus in mice
Pristane has been used as an inflammation-inducing agent, leading to myeloma development in BALB/c strain mice. It has been used as a rheumatoid arthritis-inducing agent in rats.

Features and Benefits

High quality compound suitable for multiple research applications

Other Notes

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

>230.0 °F - closed cup

Flash Point(C)

> 110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat.
Tuncel J
PLoS ONE, 11, e0155936-e0155936 (2016)
Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse.
Sanchez-Gonzalez B
Mediators of Inflammation, 2015, 313140-313140 (2015)
Marli L Moraes et al.
Journal of nanoscience and nanotechnology, 19(7), 3772-3776 (2019-02-16)
The diagnostics of the autoimmune hemolytic anemia (AIHA), a rare disease caused by autoantibody-induced hemolysis, is still prone to false positives for it is based on visual observation in the so-called Direct Coombs test. In this study, we developed a
M Satoh et al.
Clinical and experimental immunology, 121(2), 399-405 (2000-08-10)
Unlike other agents associated with drug-induced lupus, the isoprenoid alkane pristane induces autoantibodies pathognomonic of lupus, including anti-Sm, anti-dsDNA, and anti-ribosomal P in BALB/c and SJL/J mice. The susceptibility of other strains of mice to pristane-induced lupus is unknown and
K Gadó et al.
Haematologica, 86(3), 227-236 (2001-03-20)
There is no ideal animal model for human multiple myeloma (MM). All the models resemble the human disease in some respect, but none of them fulfils all the criteria of a perfect animal model. The pristane oil (2,6,10,12-tetramethylpentadecane)-induced mouse plasmacytoma

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