N3908

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody
• MDL number: MFCD00675539
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat
• enhanced validation: functional assay; Learn more about Antibody Enhanced Validation
• technique(s): immunohistochemistry (frozen sections): 1:10,000 using rat brain; indirect immunofluorescence: 1:500 using NGF-treated PC12 cells; microarray: suitable; western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
• UniProt accession no.: P07174
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: rat ... Ngfr(24596)

Description

General description

Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.

Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Immunogen

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

Application

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:

• immunoprecipitation
• immunocytochemistry
• immunohistochemistry
• immunoblotting

Biochem/physiol Actions

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable