M7441
Monoamine Oxidase B human
recombinant, expressed in baculovirus infected BTI insect cells
Synonym(s):
MAO-B
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About This Item
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
recombinant
expressed in baculovirus infected BTI insect cells
Quality Level
form
liquid
enzyme activity
≥1 U/mg
packaging
vial of ~2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAOB(4129)
General description
Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.
Application
Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression.
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.
Biochem/physiol Actions
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
Unit Definition
kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.
related product
Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Kenneth I Shulman et al.
CNS drugs, 27(10), 789-797 (2013-08-13)
This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as phenelzine, tranylcypromine and isocarboxazid, as well as the second generation selective and reversible MAOIs such as the MAO-A inhibitor, moclobemide and
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