A1346
ASB-14
Synonym(s):
3-[N,N-Dimethyl(3-myristoylaminopropyl)ammonio]propanesulfonate, Amidosulfobetaine-14
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About This Item
Empirical Formula (Hill Notation):
C22H46N2O4S
CAS Number:
Molecular Weight:
434.68
MDL number:
UNSPSC Code:
12161902
NACRES:
NA.28
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description
zwitterionic
Quality Level
Assay
≥95.0% (HPLC)
form
powder
mol wt
average mol wt >10,000
aggregation number
≥23
storage temp.
2-8°C
InChI
1S/C22H46N2O4S/c1-4-5-6-7-8-9-10-11-12-13-14-17-22(25)23-18-15-19-24(2,3)20-16-21-29(26,27)28/h4-21H2,1-3H3,(H-,23,25,26,27,28)
InChI key
UTSXERRKRAEDOV-UHFFFAOYSA-N
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General description
ASB-14 comprises alkyl tails and amidosulfobetaine headgroup.
Application
ASB-14 has been used as a component of rehydration buffer for proteomic sample preparation from Leishmania donovani.
Zwitterionic detergent. Useful for solubilization of proteins, including membrane proteins, for 2D electrophoresis.
Biochem/physiol Actions
ASB-14 is useful in proteasome extraction especially for the membrane associated proteins. Along with CHAPS (3-(3-cholamidopropyl)dimethylammonio)-1-propanesulfonate), it is employed in protein solubilization even in the presence of thiourea.
Analysis Note
ASB-14 (amidosulfobetaine-14), a membrane solubilizing zwitterionic detergent (medium chain amidosulfobetaine surfactant), may be used in protein and macromolecule research for the preparative extraction and solubilization of proteins for separation and analysis by methods such as 2D-electrophoresis. ASB-14 may be used in tissue engineering for antigen removal (AR) for xenogeneic scaffold generation. ASB-14 may be used to develop and study zwitterionic micelles.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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