S1878

Sodium (meta)periodate

≥99.0%

• Synonym(s): Sodium periodate
• Linear Formula: NaIO₄
• CAS Number: 7790-28-5
• Molecular Weight: 213.89
• EC Number: 232-197-6
• MDL number: MFCD00003534
• UNSPSC Code: 12352300
• PubChem Substance ID: 329824494
• NACRES: NA.55

Properties

• Quality Level: 300
• Assay: ≥99.0%
• form: powder
• reaction suitability: reagent type: oxidant
• pH: 3.5-5.5 (25 °C, 107 g/L)
• solubility: H₂O: 50 mg/mL
• SMILES string: [Na+].[O-]I(=O)(=O)=O
• InChI: 1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1
• InChI key: JQWHASGSAFIOCM-UHFFFAOYSA-M

Description

General description

Sodium (meta)periodate is commonly used as an oxidizing agent in organic synthesis for the oxidation of various organic substrates. It can also be used as a co-oxidant with other oxidizing reagents such as osmium tetroxide and potassium permanganate. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.

Application

Sodium (meta)periodate can be used as an oxidizing agent for the oxidation of:      

• 1,2-diols to aldehydes or ketones via oxidative cleavage.       Sulfides to sulfoxides in the presence of phase transfer catalysts.      
• Diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.      
• Phenols and their derivatives to corresponding quinones.
• Acylphosphoranes to α,β-dicarbonyl compounds.

It can also be used in the:      

• Selective alkene epoxidation and alkane hydroxylation,·
• Oxidation of carbohydrates.      
• Iodination of aromatic compounds.

Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide

Features and Benefits

NaIO₄ is a stable, selective, and cost-effective reagent that is capable of reacting under mild conditions.

Safety Information

• Pictograms: GHS03,GHS05,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H271 - H314 - H372 - H410
• Precautionary Statements: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1
• Target Organs: Thyroid
• Storage Class Code: 5.1A - Strongly oxidizing hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable