PHR1179

Chlorothiazide

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₇H₆ClN₃O₄S₂
• CAS Number: 58-94-6
• Molecular Weight: 295.72
• EC Number: 200-404-9
• MDL number: MFCD00058576
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823191
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 76; traceable to Ph. Eur. C1700000; traceable to USP 1121005
• API family: chlorothiazide
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
• InChI: 1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChI key: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• Gene Information: human ... SLC12A3(6559)

Description

General description

Chlorothiazide belongs to the class of thiazide diuretic drugs. It is used for the management of postparturient udder edema in cattle. Its mode of action involves the inhibition of chloride reabsorption in the proximal portion of distal tubule.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorothiazide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

One of the first in the thiazide class of diuretics. The effect is sparing of calcium and lithium, but increases the excretion of sodium.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8998 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H317 - H334
• Precautionary Statements: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable