93092

Triphenylphosphine

≥95.0% (GC)

• Synonym(s): Phosphorustriphenyl
• Linear Formula: (C₆H₅)₃P
• CAS Number: 603-35-0
• Molecular Weight: 262.29
• Beilstein: 610776
• EC Number: 210-036-0
• MDL number: MFCD00003043
• UNSPSC Code: 12352100
• PubChem Substance ID: 57653514
• NACRES: NA.21

Properties

• vapor density: 9 (vs air)
• Quality Level: 200
• vapor pressure: 5 mmHg ( 20 °C)
• Assay: ≥95.0% (GC)
• form: crystals
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: ligand
• impurities: ~3% triphenylphosphine oxide
• bp: 377 °C (lit.)
• mp: 77-84 °C; 79-81 °C (lit.)
• solubility: water: soluble 0.00017 g/L at 22 °C
• functional group: phosphine
• SMILES string: c1ccc(cc1)P(c2ccccc2)c3ccccc3
• InChI: 1S/C18H15P/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
• InChI key: RIOQSEWOXXDEQQ-UHFFFAOYSA-N

Description

General description

Triphenylphosphine, also referred to as PPH₃, is an organophosphorous compound. It readily forms complexes with platinum-metal group salts.

Application

• The palladium-based complexes bearing 1, 3-dibenzylbenzimidazolium with morpholine, triphenylphosphine, and pyridine derivate ligands: This study discusses the synthesis and characterization of new palladium-based complexes incorporating triphenylphosphine, providing insights into their potential catalytic activities (Aktaş et al., 2022).


• Polymer-supported triphenylphosphine: This review highlights the diverse applications of polymer-supported triphenylphosphine in organic synthesis and its significant role in promoting more sustainable and efficient chemical processes (Moussa et al., 2019).


• Application prospects of triphenylphosphine-based mitochondria-targeted cancer therapy: The review focuses on the utilization of triphenylphosphine for developing mitochondria-targeted drugs, emphasizing its potential in cancer therapy (Cheng et al., 2023).

Safety Information

• Pictograms: GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H317,H318,H372
• Precautionary Statements: P260 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1B - STOT RE 1 Inhalation
• Target Organs: Central nervous system,Peripheral nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): 356.0 °F - closed cup
• Flash Point(C): 180 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves