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73529

Supelco

Clobetasol

≥95.0% (HPLC), pharmaceutical impurity standard

Synonym(s):

Clobetasol propionate impurity G (PhEur), (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H28ClFO4
CAS Number:
25122-41-2
Molecular Weight:
410.91
EC Number:
246-633-8
MDL number:
MFCD03695616
UNSPSC Code:
41116107
PubChem Substance ID:
329763802

grade

analytical standard

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% related substances
≤5.0% solvents
≤5.0% water

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl

InChI

1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

FCSHDIVRCWTZOX-DVTGEIKXSA-N

Application

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS7533V
BCBR2508V
BCBP5329V
BCBM8380V
BCBL7144V

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S Yawalkar et al.
Journal of the American Academy of Dermatology, 25(6 Pt 2), 1137-1144 (1991-12-01)
Both halobetasol propionate and clobetasol 17-propionate exerted very marked antiinflammatory, antiproliferative, and vasoconstrictive effects during evaluation in a range of dermatopharmacologic models. Halobetasol propionate was distinctly more potent than clobetasol 17-propionate in the ultraviolet-induced dermatitis inhibition assay in guinea pigs
Kai-Li Mao et al.
Colloids and surfaces. B, Biointerfaces, 160, 704-714 (2017-10-17)
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through
Tina Bhutani et al.
The Journal of dermatological treatment, 23(1), 11-15 (2011-01-25)
Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, double-blind trials suggests that clobetasol spray is, in fact, slightly
E A Olsen et al.
Journal of the American Academy of Dermatology, 15(2 Pt 1), 246-255 (1986-08-01)
Clobetasol-17-propionate, the most potent of currently available topical steroids as predicted by the vasoconstrictor assay, has just been approved in the United States. In psoriasis, it has proved significantly more effective than class II steroids and as or more effective
O Yélamos et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 35(1), 143-149 (2020-05-05)
Treatment response for psoriasis is typically evaluated using clinical scores. However, patients can relapse after clinical clearance, suggesting persistent inflammation. Dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) can non-invasively improve treatment response assessment. To compare the clinical
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