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Key Documents

15307

Sigma-Aldrich

Chloral hydrate

≥99%

Synonym(s):

Trichloroacetaldehyde hydrate

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About This Item

Linear Formula:
Cl3CCH(OH)2
CAS Number:
Molecular Weight:
165.40
Beilstein:
1698497
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥99%

reaction suitability

reagent type: cross-linking reagent

drug control

USDEA Schedule IV

impurities

chlor alcoholate, complies
organic volatile impurities, complies (GC)
residual solvents Toluene, Chloroform, Benzene, complies
≤0.002% heavy metals (as Pb)
≤0.1% non-volatile matter

ign. residue

≤0.1% (as SO4)

pH

2.8-5.5 (20 °C, 10%)

mp

57 °C (lit.)

anion traces

chloride (Cl-): ≤70 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(O)C(Cl)(Cl)Cl

InChI

1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H

InChI key

RNFNDJAIBTYOQL-UHFFFAOYSA-N

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Application

Chloral hydrate is used in many protocols as a clearing agent for the microscopic examination of plant tissues without disrupting the cellular features.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Rois A S and Caperta A D
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An improved clearing and mounting solution to replace chloral hydrate in microscopic applications.
Villani T S
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Cheng Y, et al.
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Stephanie K West et al.
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To report the largest study on the safety and effectiveness of sedation in paediatric ophthalmology in a nurse-led outpatient sedation unit. Retrospective cohort study reviewing all children who underwent sedation from January 2006 to December 2010. Patients were sedated with

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