MA1HC10FS1

Millistak+^® HC Pod Depth Filter

A1HC, cellulose, filtration area 1.1 m², hydrophilic

• Synonym(s): Millistak+ HC Pod Depth Filter, A1HC media series, 1.1 m ² surface area
• UNSPSC Code: 23151806
• eCl@ss: 32031690

Properties

• material: cellulose ; filter aid (inorganic); glass fiber-reinforced polypropylene ; mixed cellulose esters (MCE)
• Quality Level: 400
• description: Post-TFF (Prostak^™) clarification fluids
• feature: hydrophilic
• manufacturer/tradename: Millistak+^®
• parameter: 1 bar max. differential pressure (15 psid) at 80 °C (Forward); 1 bar max. inlet pressure (15 psi) at 80 °C; 2.1 bar max. differential pressure (30 psid) at 25 °C (Forward); 2.1 bar max. differential pressure (30 psid) at 25 °C (Reverse); 3.5 bar max. inlet pressure (50 psi) at 25 °C
• H: 32 cm (12.5 in.)
• L: 62 cm (24.2 in.)
• filtration area: 1.1 m²
• impurities: <0.25 EU/mL bacterial endotoxins (LAL test, Aqueous extraction)
• gravimetric extractables: 39-69 mg/m²
• total organic carbon (TOC) residue: 720-1260 ppb
• input: sample type liquid
• conductivity: 8.66-10.5 μS/cm at 25 °C (product water)
• filter grade: A1HC

Description

General description

The Millistak+^® depth filter media is offered in a scalable, disposable format providing greater flexibility because of its unique modular design. The Millistak+^® MA1HC10FS1 comes in a High Capacity POD format featuring a 32 cm (H) x 62 cm (L) and a filtration area of 1.1 m².

This A1HC media series delivers optimal performance through a gradient density matri, ideal for post-TFF clarification fluid applications. Millistak+^® Pod filters are available in three distinct series of media grades in order to meet your specific needs - DE, CE and HC.

The Millistak+^® Pod system is ideal for a wide variety of primary and secondary clarification applications, including cell cultures, yeast and E. coli lysates post centrifuge, E. coli refolds, media, vaccines, plasma proteins and sera.

Easy to Use

With the compact, modular design of our Millistak+^® new Pod system, you can increase productivity and shorten cycle times.

Installation and setup of the Pod system is simple and straightforward. The unique design of the disposable adapters and disposable manifolds makes it easy to connect the Pod filters to rest of the unit operations in the process. The self-contained and disposable nature of the system protects operators from exposure to biohazards and eliminates maintenance as well as cleaning validation requirements.

Application

Post-TFF (Prostak^™) clarification fluids

Features and Benefits

• Low hold-up volume for greater product yield
• Broad range of media types offered in single and multilayer products
• Millistak+^® HC dual-action media improves prefiltration and compresses clarification
• Flexible, modular format offers scalability from 5 to 12,000 liters or more
• Patented disposable design eliminates need for housing, CIP or cleaning validation
• Self-contained Pod filters protect operators from exposure to biohazards
• Robust construction is easy to use and set up
• Smaller footprint facilitates use in tight spaces

Specifications

Filter Grade: A1HC

Per 24 hour soak in 10 L pure water post autoclave (1 cycle of 60 minutes at 123 °C) and pure water flush of 100 L/m² (10 L/ft²) of media surface area:
Sodium: <3.0 mg/ft²
Calcium: <0.7 mg/ft²
Magnesium: <0.2 mg/ft²
Mercury: <0.01 mg/ft²
Chromium: <0.01 mg/ft²
Aluminum: <0.01 mg/ft²
Potassium: <0.01 mg/ft²
Lead: <0.01 mg/ft²
Arsenic: <0.01 mg/ft²
Cobalt: <0.01 mg/ft²
Iron: <0.01 mg/ft²
Manganese: <0.01 mg/ft²
Titanium: <0.01 mg/ft²
Zinc: <0.01 mg/ft²

Preparation Note

Sterilization Method
1 autoclave cycle of 60 min @ 123 °C

Analysis Note

Gravimetric Extractables: After 24 hour static soak in pure water (Type 1 DI Water) post autoclave (1 cycle of 60 minutes at 123 °C) and pure water flush of 100 L/m² of media surface area

Product Water Conductivity at 25°C: post autoclave (1 cycle of 60 minutes at 123 °C) and pure water flush of 10 liters per ft² (100 L/m²) of media surface area

Total Organic Carbon (TOC) Residue: post autoclave (1 cycle of 60 minutes at 123 °C) and pure water flush of 100 L/m² of media surface area

Legal Information

MILLISTAK+ is a registered trademark of Merck KGaA, Darmstadt, Germany

Prostak is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H350i,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B Inhalation - STOT RE 2 Inhalation
• Target Organs: Lungs
• Storage Class Code: 10-13 - German Storage Class 10 to 13
• WGK: WGK 3