573096

STAT3 Inhibitor Peptide, Cell-Permeable

The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.

• Synonym(s): STAT3 Inhibitor Peptide, Cell-Permeable, PpYLKTK-mts, STAT3 Inhibitor IV
• Empirical Formula (Hill Notation): C₉₂H₁₅₇N₂₀O₂₄P
• Molecular Weight: 1958.32
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Supplied as a trifluoroacetate salt.

A cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.

A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Blocker of Stat3 activation

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH

Other Notes

Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable