700024P

7α,27-dihydroxycholesterol

Avanti Research^™ - A Croda Brand

• Synonym(s): 111116
• Empirical Formula (Hill Notation): C₂₇H₄₆O₃
• CAS Number: 4725-24-0
• Molecular Weight: 418.65
• MDL number: MFCD22416719
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 1 mg (700024P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@H]1[C@H]2[C@H]3[C@@]([C@H](CC3)[C@@H](CCCC(CO)C)C)(CC[C@@H]2[C@]4(CC[C@@H](CC4=C1)O)C)C
• InChI: 1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
• InChI key: RXMHNAKZMGJANZ-DTTSCKGMSA-N

Description

General description

7α,27-dihydroxycholesterol (7α,27-di-OHC) is an oxysterol with oxidized side chains. 7α,27-dihydroxycholesterol (7α27-OHC) is synthesized by the hydroxylation of 27-Hydroxycholesterol (27-OHC) and is a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).

Biochem/physiol Actions

7α,27-dihydroxycholesterol (7α,27-di-OHC) is one of the metabolite screened in pathological conditions such as neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome and diabetes by lipidomics analysis of human specimens. Upon the lipopolysaccharide activation, the levels of 7α,27-di-OHC decreases.7α27-OHC is a ligand for Epstein-Barr virus-induced gene 2 (EBI2).

Packaging

5 mL Amber Glass Screw Cap Vial (700024P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids