700019P

25-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• Synonym(s): 110816
• Empirical Formula (Hill Notation): C₂₇H₄₆O₂
• CAS Number: 2140-46-7
• Molecular Weight: 402.65
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: cholest-5-ene-3β,25-diol
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (700019P-10mg); pkg of 1 × 100 mg (700019P-100mg); pkg of 1 × 5 mg (700019P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
• InChI key: INBGSXNNRGWLJU-ZHHJOTBYSA-N

Description

General description

25-hydroxy-cholesterol is a side chain substituted oxysterol. Avanti′s unique sterol reverses cataracts in mice. Gestwicki′s team ...... settled on compound 29, a steroid found naturally in the bloodstream but not in the lens, which has no blood supply. Mice with age-related and hereditary cataracts received drops in the right eye, whereas the left eye went untreated. After just a few weeks, the treated eye was visibly clearer, says Gestwicki, who conducted the work while at the University of Michigan. Cataract severity is measured on a scale of zero to four, with four being the worst case. On average, mice in the study had about a one-grade improvement in cataract severity after 4 weeks of treatment. Science DOI: 10.1126/science.aad7400 It has been recently shown that activation of a macrophage toll-like receptor (TLR) by microbial antigens induces synthesis of 25-hydroxycholesterol, and that this oxysterol potently suppresses IgA production.

Application

• Inhibition Mechanism of SARS-CoV-2 Infection by a Cholesterol Derivative, Nat-20(S)-yne: This study explores how a cholesterol derivative, related to 25-hydroxycholesterol, inhibits SARS-CoV-2 infection, highlighting its potential in therapeutic applications for viral infections (Murae et al., 2024).


• 25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis: Demonstrates the role of 25-hydroxycholesterol in cancer biology, particularly in enhancing tumor growth and metastasis, providing insights for targeted cancer therapies (He et al., 2024).


• 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages: Investigates how 25-hydroxycholesterol influences immune cells, particularly in the context of immune suppression and potential anti-inflammatory therapies (Xiao et al., 2024).

Packaging

5 mL Amber Glass Screw Cap Vial (700019P-100mg)

5 mL Amber Glass Screw Cap Vial (700019P-10mg)

5 mL Amber Glass Screw Cap Vial (700019P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable