Skip to Content
Merck
All Photos(1)

Key Documents

934321

Sigma-Aldrich

L-Valyl-L-citrulline

≥95%

Synonym(s):

L-Valyl-N5-(aminocarbonyl)-L-ornithine, Val-Cit

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C11H22N4O4
CAS Number:
159858-33-0
Molecular Weight:
274.32
MDL number:
MFCD32069532
UNSPSC Code:
12352209
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder or crystals

color

off-white to light yellow

storage temp.

2-8°C

Application

This is a cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC & Bioconjugation).

Features and Benefits

Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. The Boc group can be deprotected under acidic conditions to generate a free amine group. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service