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765090

Sigma-Aldrich

Polyethylenimine, linear

average Mn 10,000, PDI ≤1.3

Synonym(s):

PEI

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About This Item

Linear Formula:
(CH2CH2NH)n
CAS Number:
9002-98-6
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

mol wt

average Mn 10,000

mp

48-53 °C

PDI

≤1.3

storage temp.

2-8°C

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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General description

Polyethylenimine (linear) is a versatile cationic polymer with a high transfection efficiency. It is used as a gene delivery reagent. It is a non-lipid polycation that can be used to transfect oligonucleotides and plasmid into cells in vitro and in vivo.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Bromodomain and extra-terminal (BET) protein inhibitors suppress chondrocyte differentiation and restrain bone growth
Niu N, et al.
The Journal of biological chemistry, 291(52), 26647-26657 (2016)
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou S, et al.
The journal of gene medicine, 2(2), 128-134 (2000)
A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
Wiseman JW, et al.
Gene Therapy, 10(19), 1654-1654 (2003)
Marie-Elise Bonnet et al.
Pharmaceutical research, 25(12), 2972-2982 (2008-08-19)
The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for nucleic acid delivery due to
Dae Hee Lee et al.
Biomaterials, 171, 34-45 (2018-04-22)
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative.
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Articles

Delivery of Nucleic Acids Using Polymers

Delivery of Nucleic Acids Using Polymers

Functionalized PEI and Its Role in Gene Therapy
Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functional Polymers for Biomedical Applications

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

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