202371
Poly(ethylene glycol)
average Mn 300, hydroxyl
Synonym(s):
Polyethylene glycol, PEG
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About This Item
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
12352104
PubChem Substance ID:
NACRES:
NA.23
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product name
Poly(ethylene glycol), average Mn 300
form
viscous liquid
mol wt
Mn 285-315
average Mn 300
refractive index
n20/D 1.463
pH
6-7 (23 °C, at 10 g/l)
viscosity
5.8 cSt(210 °F)(lit.)
mp
−15-−8 °C (lit.)
density
1.125 g/mL at 25 °C
Mw/Mn
1.1 (typical)
Ω-end
hydroxyl
α-end
hydroxyl
SMILES string
C(CO)O
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
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General description
Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks, PEG can have high water content, forming "hydrogels". Hydrogel formation can be initiated by either crosslinking PEG by ionizing radiation or by covalent crosslinking of PEG macromers with reactive chain ends. PEG is a suitable material for biological applications because it does not trigger an immune response.
Application
- PEG modification increases thermostability and inhibitor resistance of Bst DNA polymerase.: This study demonstrates that polyethylene glycol (PEG) modification significantly enhances the thermostability and inhibitor resistance of Bst DNA polymerase, highlighting PEG′s potential in improving enzyme performance for biotechnological applications (Yang et al., 2024).
- Development of Lyophilized Eukaryotic Cell-Free Protein Expression System Based on Leishmania tarentolae.: The incorporation of PEG in the lyophilization process of a cell-free protein expression system demonstrates its role in enhancing the stability and efficiency of biotechnological workflows (Alfaro-Palma et al., 2024).
- A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer.: This review highlights the application of PEGylated nanomaterials in photodynamic therapy, emphasizing its significance in improving biocompatibility and therapeutic efficacy in cancer treatments (Singh et al., 2024).
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
428.0 °F - closed cup
Flash Point(C)
220.00 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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