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Merck

EGFR

epidermal growth factor receptor

Synonyms:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
Gene ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Phospho-EGFR (pSer1070) ELISA Kit, for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates,
Species
human
Phospho-EGFR (pTyr1086) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1086) and pan-egfr in cell and tissue lysates,
Species
human
Phospho-EGFR (pTyr1045) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1045) and pan-egfr in cell and tissue lysates,
Species
human
Cell-Based ELISA for detecting phospho-EGFR (pTyr845) in cultured cell lines, 96 assays,
Species
human
Phospho-EGFR (pTyr1086) ELISA Kit, for detection of human phospho-egfr (pTyr1086) in cell and tissue lysates,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tyrphostin AG 1478, ≥98%,
Species
human, mouse
SU 5416, ≥98% (HPLC),
Species
human, mouse
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat
Genistein, from Glycine max (soybean), ~98% (HPLC),
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-EGFR PE produced in mouse, ,
Species Reactivity
horse
Application
flow cytometry
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
Species Reactivity
human
Application
ELISA
flow cytometry

immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-EGFR (PhosphoTyr992) antibody produced in mouse, clone EM-12,
Species Reactivity
human
Application
western blot
EGFR (SP84) Rabbit Monoclonal Antibody, ,
Species Reactivity
Application
Anti-EGFR antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Tyrphostin 1, ≥98%,
Species
human
Gefitinib, European Pharmacopoeia (EP) Reference Standard,
Species
human
PKI-166, ≥98% (HPLC),
Species
human
Gefitinib, ≥98% (HPLC),
Species
human
DAPH, ≥98% (HPLC), solid,
Species
human

Proteins

Product Number
Description
Species
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human
EGFR (L861Q), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
EGFR active mouse, recombinant, expressed in baculovirus infected Sf9 cells,
Species
mouse
EGFR (D746-750 C797S), Active, recombinant,
Species
human
EGFR (T790M C797S L858R), Active, PRECISIO ®Kinase, recombinant,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human EGFR,
Species
human
MISSION® esiRNA, targeting mouse Egfr,
Species
mouse