1154004

Cyclizine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 1-Benzhydryl-4-methylpiperazine hydrochloride, Marezine hydrochloride
• Empirical Formula (Hill Notation): C₁₈H₂₂N₂ · HCl
• CAS Number: 303-25-3
• Molecular Weight: 302.84
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: cyclizine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• InChI: 1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
• InChI key: UKPBEPCQTDRZSE-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Apoptotic pathways in macrophages: Cyclizine hydrochloride was studied for its ability to induce cytotoxicity and apoptosis in macrophages through both extrinsic and intrinsic pathways, suggesting its potential implications in immunomodulatory therapies (Lu et al., 2024).


• Chemometric methods in impurity analysis: Advanced chemometric methods have been employed to determine cyclizine hydrochloride along with other compounds in pharmaceutical products, highlighting its importance in ensuring the purity and efficacy of drug formulations (Saad et al., 2022).


• Anti-inflammatory effects in pharmacology: Cyclizine derivatives were synthesized and evaluated for anti-inflammatory performance on Wistar rats, providing insights into the therapeutic potential of cyclizine modifications in treating inflammation (Ahmadi et al., 2012).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable