W4262
1400W dihydrochloride
>98%, solid
Synonym(s):
N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H15N3 · 2 HCl
CAS Number:
Molecular Weight:
250.17
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
>98%
form
solid
storage condition
desiccated
originator
GlaxoSmithKline
shipped in
wet ice
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842) , NOS2(4843) , NOS3(4846)
Application
1400W dihydrochloride has been used:
- as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
- as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
- to study its efficacy on renal ischemia/ reperfusion injury in rats
- as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation
Biochem/physiol Actions
1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).
Features and Benefits
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
1400 W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia
Shi Q, et al.
Behavioural Brain Research, 319(8), 188-199 (2017)
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
E P Garvey et al.
The Journal of biological chemistry, 272(8), 4959-4963 (1997-02-21)
N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM.
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
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