SRP6172
IL-4 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
B-cell stimulatory factor 1 (BSF-1), BCGF, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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General description
Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Biochem/physiol Actions
Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens.
Physical form
Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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