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SML3663

Sigma-Aldrich

CAY10499

≥98% (HPLC)

Synonym(s):

Benzyl 4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenylcarbamate, CAY 10499, CAY-10499, LEI 103, LEI-103, LEI103, Phenylmethyl N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate, [4-(5-Methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-carbamic acid phenylmethyl ester

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About This Item

Empirical Formula (Hill Notation):
C18H17N3O5
CAS Number:
359714-55-9
Molecular Weight:
355.34
MDL number:
MFCD12912259
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

CAY10499 is a potent inhibitor against fatty acid amide hydrolase, hormone-sensitive lipase, and monoglyceride lipase (FAAH/HSL/MGL(MAGL) IC50 = 86/90/92 nM). Note: CAY10499 is reported to be irreversible by Muccioli et al. (PMID 18855964) and reversible by Minkkila et al. (PMID 19472270). Reported IC50 values vary depending greatly on pre-incubation time, substrates, enzyme source, as well as other experimental parameters employed.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Orly Laufman et al.
Cell, 178(2), 275-289 (2019-06-18)
Positive-stranded RNA viruses extensively remodel host cell architecture to enable viral replication. Here, we examined the poorly understood formation of specialized membrane compartments that are critical sites for the synthesis of the viral genome. We show that the replication compartments
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
Anna Minkkilä et al.
ChemMedChem, 4(8), 1253-1259 (2009-05-28)

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