SML3340
Sgl1 inhibitor Hit 1
≥98% (HPLC)
Synonym(s):
4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol
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About This Item
Empirical Formula (Hill Notation):
C17H22N2O3S
CAS Number:
Molecular Weight:
334.43
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1
Biochem/physiol Actions
Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
Nature Communications, 12, 5885-5885 (2021)
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