SML2660

ABT-100 Hydrochloride

≥98% (HPLC)

• Synonym(s): 6-[(2S)-2-(4-Cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4′-(trifluoromethoxy)-1,1′-biphenyl-3-carbonitrile hydrochloride, 6-[(2S)-2-(4-Cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4′-(trifluoromethoxy)[1,1′-biphenyl]-3-carbonitrile hydrochloride, A-409100 Hydrochloride, ABT 100, [1,1′-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4′-(trifluoromethoxy)- hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₁₉F₃N₄O₃ · HCl
• CAS Number: 852926-14-8
• Molecular Weight: 540.92

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• Inchi Code: 1S/C27H19F3N4O3.ClH/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30;/h2-12,15,17,35H,16H2,1H3;1H/t26-;/m0./s1
• InChI key: YDYNOCJMVNXQKV-SNYZSRNZSA-N
• SMILES string: O[C@](COC1=C(C2=CC=C(OC(F)(F)F)C=C2)C=C(C=C1)C#N)(C3=CN=CN3C)C(C=C4)=CC=C4C#N.Cl

Description

Biochem/physiol Actions

ABT-100 is an orally available, highly potent and highly selective inhibitor of farnesyltransferase (FTase). ABT-100 exhibits broad spectrum antitumor activities in xenograft models.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable