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SAB4501790

Sigma-Aldrich

Anti-LY6E antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Ly-6E, Lymphocyte antigen 6E, RIG-E, Retinoic acid-induced gene E protein, Thymic shared antigen 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 13 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500

NCBI accession no.

Q16553

UniProt accession no.

Q16553

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LY6E(4061)

General description

Anti-LY6E Antibody detects endogenous levels of total LY6E protein.
Anti-LY6E Antibody detects endogenous levels of total LY6E protein. LY6E (lymphocyte antigen 6 family member E) is a glycosylphosphatidylinositol-anchored, interferon (IFN)-inducible protein, that is located on human chromosome 8q24. It is also called as RIG-E.

Immunogen

The antiserum was produced against synthesized peptide derived from human LY6E.

Immunogen Range: 17-66

Biochem/physiol Actions

LY6E (lymphocyte antigen 6 family member E) controls T lymphocytes proliferation, differentiation and development. It induces HIV-1 Infection. Overexpression of LY6E gene in the peripheral blood cells of individuals with SLE (systemic lupus erythematosus) is associated with lupus activity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Interferon-inducible LY6E Protein Promotes HIV-1 Infection.
Yu J, et al.
Journal of Biochemistry, 292(11), 4674-4685 (2017)
Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients.
J Tang, et al.
Lupus, 17(9), 805-813 (2008)
RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.
M Mao, et al.
Proceedings of the National Academy of Sciences of the USA, 93(12), 5910-5914 (1996)

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