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Key Documents

SAB3500765

Sigma-Aldrich

Anti-TLR4 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

92 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

ELISA: suitable
immunohistochemistry: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TLR4(7099)

General description

Toll-like receptor 4 (TLR4) belongs to the interleukin-1 receptor (IL-1R) family. It is highly polymorphic and is located on human chromosome 9q33.1.

Immunogen

Antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TLR4.

Biochem/physiol Actions

Toll-like receptor 4 (TLR4) acts as the receptor for LPS (lipopolysaccharides ), a gram-negative bacterial cell wall component. Mutations in TLR4 affects mRNA and protein expression in colorectal cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500765.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer.
Proenca MA, et al.
World Journal of Gastroenterology, 21(25), 7730-7730 (2015)
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease.
Liu B, et al.
Journal of Immunology, 177(10), 6880-6888 (2006)
Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes.
Matsumura T, et al.
Journal of Interferon & Cytokine Research, 20(10), 915-921 (2000)
Xueqin Huang et al.
International immunopharmacology, 22(1), 266-272 (2014-07-17)
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by various immunological abnormalities. Dihydroartemisinin (DHA), a metabolite of artemisinin, has been recently reported to exhibit immunosuppressive properties. The present study aims to determine the effects of DHA on spleen
Jie Dong et al.
The FEBS journal, 281(17), 3803-3815 (2014-07-06)
Interaction between pneumococcal virulence factors and innate immune receptors triggers host responses via specific signaling pathways after infection. By generating a deficient mutant, we show here that, compared with the wild-type parent strain, glycosyl hydrolase 25 relating to invasion protein

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