P5648

β-Propiolactone

Grade II, ≥90%

• Synonym(s): Oxetan-2-one, 3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone
• Empirical Formula (Hill Notation): C₃H₄O₂
• CAS Number: 57-57-8
• Molecular Weight: 72.06
• EC Number: 200-340-1
• MDL number: MFCD00005169
• UNSPSC Code: 12352103
• PubChem Substance ID: 24898684
• NACRES: NA.77

Properties

• type: Grade II
• Assay: ≥90%
• refractive index: n20/D 1.412 (lit.)
• bp: 162 °C (lit.)
• mp: −33 °C (lit.)
• density: 1.146 g/mL at 25 °C (lit.)
• storage temp.: −20°C
• SMILES string: O=C1CCO1
• InChI: 1S/C3H4O2/c4-3-1-2-5-3/h1-2H2
• InChI key: VEZXCJBBBCKRPI-UHFFFAOYSA-N

Description

General description

β-Propiolactone is an alkylating agent which is mainly used in veterinary vaccines. It will not interfere with the antigenicity of vaccine.

Application

β-Propiolactone has been used for Influenza virus deactivation.

Caution

Insoluble polymers may form during storage.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H315,H319,H330,H350
• Precautionary Statements: P202 - P260 - P264 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 158.0 °F - closed cup
• Flash Point(C): 70 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves