M9434

Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat

clone 14, tissue culture supernatant

• Synonym(s): Anti-MBP
• MDL number: MFCD01324037
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rat
• Quality Level: 200
• conjugate: unconjugated
• antibody form: tissue culture supernatant
• antibody product type: primary antibodies
• clone: 14, monoclonal
• contains: 0.09% sodium azide
• species reactivity: horse, chicken, human
• technique(s): ELISA: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• isotype: IgG
• UniProt accession no.: P02686
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MBP(4155)

Description

General description

Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.

Specificity

Recognizes amino acids 36-50 of myelin basic protein.

Immunogen

bovine myelin basic protein.

Biochem/physiol Actions

Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.

Preparation Note

Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids